Resources

The brain age index may be a useful biomarker associated with dementia and could have utility as a screening tool for the presence of underlying neurodegenerative disease and monitoring of disease progression.

This study’s findings suggest that experts can identify whether EEGs contain IEDs with substantial reliability. Lower reliability regarding individual IEDs may be largely explained by various experts applying different thresholds to a common underlying statistical model.

Training with a large data set enables automated sleep staging that compares favorably with human scorers. Because testing was performed on a large and heterogeneous data set, the performance estimate has low variance and is likely to generalize broadly.

Ketamine is an NMDA receptor antagonist commonly used to maintain general anesthesia. At anesthetic doses, ketamine causes high power gamma (25-50 Hz) oscillations alternating with slow-delta (0.1-4 Hz) oscillations. These dynamics are readily observed in local field potentials (LFPs) of non-human primates (NHPs) and electroencephalogram (EEG) recordings from human subjects. Here, we characterize ketamine’s neural dynamics using a hidden Markov model (HMM).

We studied how WM is integrated across hemifields by recording neural activity bilaterally from prefrontal cortex. Around the time of transfer, synchrony between the two prefrontal hemispheres peaked in theta and beta frequencies, with a directionality consistent with memory trace transfer. This illustrates how the two cortical hemispheres can stitch together WM traces across visual hemifields.

These results provide new insights into the neural basis required for light to influence mood & learning.

This is the first study of large ensembles of single neurons during seizures in persons with epilepsy. Contrary to the traditional view, neuronal spiking activity during seizures was highly heterogeneous and changed significantly preceding clinical onset.

Unconsciousness is linked to cortical and thalamic slow frequency synchrony coupled with decreased spiking, and loss of higher-frequency dynamics. This may disrupt cortical communication/integration.